Personalised Embryo transfer through Endometrial receptivity array.

The commonest question you ask a fertility specialist is why does my IVF fail with good embryos and a good endometrium.

IVF cycle can also fail even when Donor egg or embryo is used. There could be a problem in the sperm or implantation failure due to defective endometrial receptivity. Even the best embryo will to give pregnancy if the uterus is not adequate to sustain normal implantation and placentation.

Repeated IVF failure require complete rework of all factors. There are various causes of repeated IVF failure and not just one. Repeated IVF failure is a frustrating experience for the couple in terms of emotions and finance. Evaluation starts from the endometrium. It goes till the sperm morphology and DNA.

Using 5% Oxygen for embryo cultures to get better embryos. Research has shown using low physiologic oxygen during embryo culture will result in faster developing embryos with better implantation chances.

In one study, with the use of intramuscular progesterone, a circulating level >20 ng/mL was associated with lower implantation rates, suggesting that excessive systemic (or vaginal) absorption could accelerate the pace of endometrial development. In some women , just changing the progesterone support will help.

With such methods, its possible to do personalised embryo transfer. We just shift the day of transfer to suite optimal progesterone duration.

Correction of the individual displacements of the window of implantation leads to a personalised of the embryo transfer. This means that to allow a synchronized embryo transfer, in addition to information about the embryo, the diagnosis of a receptive endometrium is also obtained.

• Complete evaluation of all factors
• Good Stimulation protocol
• Get Best quality embryos
• Pre-implantation genetic screening / Diagnosis
• Personalised embryo transfer
• Embryo freezing

• A capable embryo must be accurately deposited and retained in an optimal location of the uterine cavity. The endometrium must be receptive and synchronized to the developmental stage of the embryo.
• The uterus must be physiologically and anatomically adequate.
• There should not be the presence of circulating factors capable of disrupting normal implantation and placentation, nor the absence of specific factors required for endometrial receptivity.